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Observe Carefully (1)pentobarbital will minimize the extent or result of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead into a lessen in fentanyl plasma concentrations, insufficient efficacy or, quite possibly, development o